翻訳と辞書 ・ DTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase ・ DTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase ・ DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase ・ DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase ・ DTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase ・ DTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase ・ DTDP-4-amino-4,6-dideoxy-D-glucose transaminase ・ DTDP-4-amino-4,6-dideoxygalactose transaminase ・ DTDP-4-dehydro-6-deoxyglucose reductase ・ DTDP-4-dehydrorhamnose 3,5-epimerase ・ DTDP-4-dehydrorhamnose reductase ・ DTDP-6-deoxy-L-talose 4-dehydrogenase ・ DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) ・ DTDP-dihydrostreptose—streptidine-6-phosphate dihydrostreptosyltransferase ・ DTDP-galactose 6-dehydrogenase ・ DTDP-glucose 4,6-dehydratase ・ DTDP-L-rhamnose 4-epimerase ・ DTE ・ DTE (direct to edit) ・ DTE Energy ・ DTE Energy Electric Company ・ DTE Energy Headquarters ・ DTE Energy Music Theatre ・ DTE80 ・ Dtech it education ・ DTED ・ DTEK ・ DTEK Academy ・ DTEK Dniproenergo ・ Dtella
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DTDP-glucose 4,6-dehydratase : ウィキペディア英語版 | DTDP-glucose 4,6-dehydratase
In enzymology, a dTDP-glucose 4,6-dehydratase () is an enzyme that catalyzes the chemical reaction :dTDP-glucose dTDP-4-dehydro-6-deoxy-D-glucose + H2O Hence, this enzyme has one substrate, dTDP-glucose, and two products, dTDP-4-dehydro-6-deoxy-D-glucose and H2O. == Structure and mechanism of action ==
The first protein structures of a dTDP-glucose 4,6-dehydratase (RmlB) were completed by Jim Thoden in the Hazel Holden lab (University of Wisconsin–Madison) and Simon Allard in the Jim Naismith lab (University of St Andrews). Further structural, mutagenic, and enzymatic studies by both groups, along with important mechanistic work by the W. Wallace Cleland and Perry Frey groups have led to a good understanding of this enzyme. In brief summary, the enzyme is a dimeric protein with a Rossman fold; it uses the tightly bound coenzyme NAD+ for transiently oxidizing the substrate, activating it for the dehydration step.
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